Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue
AssigneeNeoMend, Inc.
InventorsGregory M Cruise, Olexander Hnojewyj
Life of this patent
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Abstract
A biocompatible and biodegradable hydrogel compound, which is free of a hemostatic agent, is applied to arrest the flow of blood or fluid from body tissue. The compound preferably includes a protein comprising recombinant or natural serum albumin, which is mixed with a polymer that comprises poly(ethylene) glycol (PEG), and, most preferably, a multi-armed PEG polymer.
Claims75
A biocompatible and biodegradable material applied to arrest the flow of blood or to seal tissue comprising a mixture of a protein solution comprising recombinant or natural human serum albumin at a concentration of about 25% or less and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, wherein, upon mixing, the protein solution and the polymer solution cross-link to form a mechanical non-liquid covering structure without of a photo-intiator and ultraviolet light energy.
A biocompatible and biodegradable material applied to arrest the flow of blood or to seal tissue comprising a mixture of a protein solution including a buffer having a concentration of about 0.3 M to 0.4 M, and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, wherein, upon mixing, the protein solution and the polymer solution cross-link to form a mechanical non-liquid covering structure.
A biocompatible and biodegradable material applied to arrest the flow of blood or to seal tissue comprising a mixture of a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, the polymer comprising a compound of the formula PEG-(DCR-CG)n, where PEG is poly(ethylene glycol), DCR is a degradation control region, CG is a cross-linking group, and n is equal to or greater than three, wherein, upon mixing, the protein solution and the polymer solution cross-link to form a mechanical non-liquid covering structure.
A biocompatible and biodegradable material applied to arrest the flow of blood or to seal tissue comprising a mixture of a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of four, wherein, upon mixing, the protein solution and the polymer solution cross-link to form a mechanical non-liquid covering structure.
A biocompatible and biodegradable material applied to arrest the flow of blood or to seal tissue comprising a mixture of a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, the polymer solution including poly(ethylene glycol)tetra-succinimidyl succinate wherein, upon mixing, the protein solution and the polymer solution cross-link to form a mechanical non-liquid covering structure.
Dependencies are inferred from the claim text.