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US 6,455,585 B1Granted
Esters derived from substituted phennyl-cyclohexyl compounds
AssigneeVita-Invest, S.A.
InventorsJuan Carlos Del Castillo Nieto, Joan Huguet Clotet, Elisabet De Ramon Amat, Maria Chalaux Freixa, Marisabel Mourelle Mancini
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Abstract
New esters derived from substituted phenyl-cyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new compounds of general formula (I) have a higher analgesic activity, a lower toxicity and a longer effective time period than Tramadol.
Claims11
A Compound of formula (I):
- R2 is:
- OH;
- R3 is:
- H;
- or R2 and R3 together form a double bond;
- R4 is:
- H or C1-C2 alkyl;
- R5 is:
- H, NH2, NH—R11 or O—R11;
- R6 is:
- H, CO—R11, O—R11 or halogen;
- R7 is:
- H, C1-C5 alkyl, C2-C5 O-alkenyl, phenyl, or R6 and R7 are —CH═CR12—CR13═CH—, forming an unsubstituted or substituted with R12 or R13 condensed aromatic ring;
- R8 is:
- OH, —O—CO—N(CH3)2 or NH—R11;
- R11 is:
- phenyl;
- phenyl unsubstituted or substituted by 1 or more of the following substituents:
- halogen (Cl, Br, I), NO2, C1-C6 alkyl, C2-C6 alkenyl, OH, or NH2;
- R12 and R13 are:
- H, or C1-C3 O-alkyl, whether equal or different;
- its salts and optical isomers.
19 more elements
Dependencies are inferred from the claim text.