Hepatitis E virus vaccine and method
AssigneeGenelabs Technologies, Inc.
InventorsGregory R. Reyes, Daniel W. Bradley, Jr-Shin Twu, Michael A. Purdy, Albert W. Tam, Krzysztof Z. Krawczynski, Patrice O. Yarbough
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Abstract
Antigen and antibody vaccine composition effective in preventing hepatitis E virus (HEV) infection are disclosed. The antigen composition includes peptides corresponding to carboxyl terminal end regions of the second and third open reasing frames of the HEV genome. The composition is effective in preventing HEV infection after vaccination. The antibody composition contains an antibody effective to block HEV infection of human primary hepatocytes in culture.
Claims5
A method of preventing or treating Hepatitis E Virus (HEV) infection in an individual, comprising
- administering to the individual, by parenteral injection, a vaccine composition containing antibodies capable of neutralizing HEV infection, as evidenced by the ability of the composition to block HEV infection of primary human hepatocyte cells in culture, and where said composition contains an antibody which is immunoreactive with a peptide containing the C-terminal 48 amino acids of the capsid protein encoded by the second open reading frame of the HEV genome.
Dependencies are inferred from the claim text.