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US 6,452,039 B1Granted
Endothelin antagonist
OwnerRyuji Uenoinventor
Life of this patent
Estimating the term…
Abstract
An endothelin antagonist comprising as the active ingredient a prostanoic acid derivative wherein the α-chain has eight or more skeletal carbon atoms.
Claims6
A compound represented by the general formula (III):
- wherein L and M are hydrogen, hydroxy, halogen, lower alkyl, hydroxy(lower)alkyl, or oxo wherein at least one of L and M is a group other than hydrogen, and the five-membered ring may have at least one double bond;
- A′ is —COOH, or its finctional derivatives;
- B′ is —CH2—CH2—;
- Z′ is
- X1 and X2 are hydrogen, lower alkyl, or halogen wherein at least one of X1 and X2 is a halogen;
- R1′ is a divalent saturated or unsaturated aliphatic hydrocarbon residue having 8 carbon atoms, which is unsubstituted or substituted by halogen, oxo, or aryl;
- R2 is a single bond or lower alkylene;
- and
- R3 is lower alkyl, lower alkoxy, cyclo(lower)alkyl, aryl, or aryloxy.
6 more elements
A compound represented by the general formula (IV):
- wherein L and M are hydrogen, hydroxy, halogen, lower alkyl, hydroxy(lower)alkyl, or oxo wherein M is a group other than hydrogen, and the five-membered ring may have at least one double bond;
- A″ is —COOH, or its functional derivatives;
- B″ is —CH2—CH2—, or —CH═CH—;
- Z″ is
- X1 and X2 are independently hydrogen, lower alkyl, or halogen;
- R1′ is a divalent saturated or unsaturated aliphatic hydrocarbon residue having 8 carbon atoms, which is unsubstituted or substituted by halogen, oxo, or aryl;
- R2 is a single bond or lower alkylene;
- and
- R3 is lower alkyl, lower alkoxy, cyclo(lower)alkyl, aryl, or aryloxy.
6 more elements
A compound represented by the general formula (V):
- wherein L and M are hydrogen, hydroxy, halogen, lower alkyl, hydroxy(lower)alkyl, or oxo wherein M is a group other than hydrogen, and the five-membered ring may have at least one double bond;
- A′″ is —COOH, or its functional derivatives;
- B′″ is —CH2—CH2—, or —CH═CH—;
- Z′″ is
- X1 and X2 are independently hydrogen, lower alkyl, or halogen;
- R1′″ is a divalent saturated or unsaturated aliphatic hydrocarbon residue having 10 carbon atoms, which is unsubstituted or substituted by halogen, oxo, or aryl;
- R2 is a single bond or lower alkylene;
- and
- R3 is lower alkyl, lower alkoxy, cyclo(lower)alkyl, aryl, or aryloxy.
6 more elements
Dependencies are inferred from the claim text.