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US 6,451,777 B1Granted
Method for regulating hair growth
AssigneeThe University of Texas Southwestern Medical Center
InventorsBarton James Bradbury, Shari Joy Soper, Joseph Robert Kaczvinsky, Jr., Dorothy Limerick Bailey, Celeste Dawn Gale
Life of this patent
Estimating the term…
Abstract
A method for regulating the growth and loss of hair via the use of compositions containing a compound selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane triterpenes, derivatives of ursane triterpenes, and salts and mixtures thereof.
Claims12
A method for regulating hair growth comprising the administration to a human of a composition comprising about 0.00001% to about 99.9% of a compound selected from the group consisting of:
- a) compounds having the structure:
- where R1 is either
- 1) connected to the ring system via a single bond, either α- or β-configuration, and is selected from the group consisting of:
- H, OH, R3, OR3, OCOR3, OCOOR3, OCONHR3, and OCON(R3)2;
- halogen or
- 2) connected to the ring system via a double bond and is selected from the group consisting of a) oxygen, b) sulfur and c) R3, and
- where R2 is selected from the group consisting of:
- CH3, CH2OH, CH2OR4, CHO, CO2H, CO2R4, COHNR4, CON(R4)2, and CH2OCOR4;
- where R3 is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of:
- i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen or sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR5, OCOR5, OCOOR5, OCONHR5, or OCON(R5)2, iii) OH, iv) OR5, v) OCOR5, vi) OCOOR5, vii) OCONHR5, viii) OCON(R5)2 and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen or sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR5, OCOR5, OCOOR5, OCONHR5, and OCON(R5)2;
- where R4 is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of:
- i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR5, OCOR5, OCOOR5, OCONHR5, and OCON(R5)2 iii) OH, iv) OR5, v) OCOR5, vi) OCOOR5, vii) OCONHR5, and viii) OCON(R5)2, and
- where R5 is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups having from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, hydroxy groups, alkoxy groups and aryloxy groups and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, aryl groups, hydroxy groups, alkoxy groups and aryloxy groups, and
- b) salts of the acid forms of (a);
- and
- c) mixtures of (a) or (b).
13 more elements
Dependencies are inferred from the claim text.