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US 6,451,527 B1Granted
Methods using genetic package display for selecting internalizing ligands for gene delivery
AssigneeSelective Genetics, Inc.
InventorsDavid Larocca, Andrew Baird, Paul Kassner
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Abstract
A genetic package display system is presented for selecting internalizing ligands for gene delivery. The genetic package carries a reporter, selectable marker, or a specifically detectable nucleic acid sequence and presents a ligand on its surface. More specifically, a library of potential ligands may be screened for the ability to successfully transduce target cells.
Claims10
A method of selecting internalizing ligands displayed on a genetic package from a library of ligand displaying genetic packages, comprising:
- (a) contacting a library of ligand displaying genetic packages with a cell(s), wherein each package carries a gene encoding a detectable product which is expressed upon internalization of the package, and
- (b) detecting product expressed by the cell(s);
- and
- thereby selecting internalizing ligands displayed on agenetic package.
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Dependencies are inferred from the claim text.