Method of forming a therapeutic coating onto a surface of an implantable prosthesis
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsSyed F. A. Hossainy, Debbie Sanders-Millare, Steven Z. Wu
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Abstract
A method of coating an implantable prosthesis by applying a composition including a therapeutic substance and a fluid to the prosthesis and removing the fluid is disclosed. The fluid is not capable of significantly dissolving the therapeutic substance. A second fluid in which the therapeutic substance is soluble may be further included in the composition. Methods of providing the composition and a roughened polymeric primer layer are also disclosed.
Claims18
A method of forming a coating on an implantable prosthesis, the method comprising the acts of:
- (a) providing a composition comprising a therapeutic substance and a first fluid, said therapeutic substance being suspended as particles in said composition;
- (b) applying a polymeric primer layer to the surface of said prosthesis;
- (c) creating areas of roughness on said polymeric primer layer by sputtering polymeric material onto the surface of said primer layer;
- (d) applying said composition to said prosthesis;
- and
- (e) removing said first fluid from said prosthesis to form a coating.
A method of forming a coating on an implantable prosthesis, the method comprising the acts of:
- (a) dissolving a therapeutic substance in a first fluid to form a solution;
- (b) combining a second fluid with said solution to form a composition, wherein the addition of said second fluid causes said therapeutic substance to precipitate;
- (c) applying said composition to said prosthesis;
- and
- (d) removing said first fluid and said second fluid from said prosthesis to form a coating.
Dependencies are inferred from the claim text.