# US 6,451,321 B1 · IBDV strain in ovo administration

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- Number: US 6,451,321 B1
- Document ID: US6451321B1
- Status: Granted
- Kind: B1
- Application number: 09/878,083
- Filed: 2001-06-08
- Granted: 2002-09-17
- Earliest claimed: 2000-06-09
- Assignees: Akzo Nobel N.V.
- Inventors: Egbert Mundt; Adriaan Antonius Wilhelmus Maria Loon Van
- Web page: https://patentgrep.com/patent/US6451321B1

## CPC

- C12N 7/00: Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof (preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K39/00)
- A61K 39/12: Viral antigens
- A61P 31/12: Antivirals
- A61P 37/04: Immunostimulants
- A61K 2039/55: {characterised by the host/recipient, e.g. newborn with maternal antibodies}
- A61K 2039/552: {Veterinary vaccine}
- C12N 2720/10021: Viruses as such, e.g. new isolates, mutants or their genomic sequences
- C12N 2720/10034: Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides a novel infectious bursal disease virus, strain 689 which is suited as vaccine candidate for in ovo vaccination and is deposited at the European Collection of Cell Cultures, Salisbury, Wiltshine, United Kingdom under No. V00012609.

## Claims

### Claim 1

A virus which is infectious bursal disease virus strain 689, which does not cause severe lesions in the bursa of Fabricius after in ovo administration and is deposited at the European Collection of Cell Cultures, Salisbury, Wiltshire, SP4 OJG, United Kingdom under accession No. V00012609.

### Claim 2 (depends on 1)

A method for the propagating of the virus according to claim 1, comprising culturing the virus on a suitable substrate and harvesting the virus from the substrate.

### Claim 3 (depends on 1)

A vaccine against infectious bursal disease, comprising a virus according to claim 1 and a pharmaceutically acceptable carrier or a diluent.

### Claim 4 (depends on 3)

The vaccine according to claim 3, comprising an effective dose of 101-106 TCID50, (Tissue Culture Effective Dose 50).

### Claim 5 (depends on 4)

The vaccine according to claim 4, comprising a dose per egg of 102-105 TCID50.

### Claim 6 (depends on 3)

The vaccine according to claim 3, which additionally comprises an embryo-safe vaccine strain of another avian pathogen.

### Claim 7 (depends on 3)

A method for protecting a bird against infectious bursal disease, comprising administering an effective amount of the vaccine according to claim 3.

### Claim 8 (depends on 7)

The method of claim 7, wherein the vaccine in administered to an embryo.

### Claim 9 (depends on 8)

The method of claim 8, wherein the vaccine is administered in the amount of 101-106 TCID50.

### Claim 10 (depends on 9)

The method of claim 9, wherein the vaccine is administered in the amount of 102-105 TCID50.