Methods for stimulating T cell responses to tumor cells expressing LFA-3 and a CD28 or CTLA4 ligand
AssigneeDana-Farber Cancer Institute, Inc.
InventorsVassiliki A. Boussiotis, Gordon J. Freeman, Lee M. Nadler
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Abstract
Methods for stimulating a T cell response to a tumor cell in a subject with a tumor which involve modifying the tumor cell to express a CD2 ligand and a CD28 or CTLA4 ligand, are disclosed. Methods wherein the tumor cell is obtained from the subject and modified ex vivo to form a modified tumor cell and then the modified tumor cell is administered to the subject, are also disclosed.
Claims12
A method for stimulating a T cell response to a tumor cell in a subject with a rumor, comprising modifying the tumor cell to express LFA-3 and a CD28 or CTLA4 ligand wherein said CD28 or CTLA4 ligand is selected from the group consisting of B7-1, B7-2, and combinations Thereof, such that stimulation of a T cell response to a tumor cell occurs.
Dependencies are inferred from the claim text.