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US 6,451,032 B1Granted
Composite prosthesis for preventing post-surgical adhesions and method for obtaining same
AssigneesSofradim Production, Imedex Biomateriaux
InventorsFrançois Régis Ory, Michel Therin, Philippe Gravagna, Jean-Louis Tayot
Life of this patent
Estimating the term…
Abstract
The composite prosthesis comprises a prosthetic fabric having a three-dimensional structure separating two surfaces, one of which is open to post-surgical cell colonization. The composite prosthesis further comprises at least one film of a collagenous material linked to the other surface of the prosthetic fabric. The composite prosthesis may be used to prevent post-surgical adhesion.
Claims52
Composite prosthesis, comprising:
- (a) a prosthetic fabric having a three-dimensional structure separating two surfaces of the fabric, at least one of said surfaces being open to any postsurgical cell colonization, and
- (b) at least one film of a cross-linked collagenous material that is linked, at least on a surface of the film, to the other said surface of said fabric, wherein said collagenous material comprises collagen having helical structure which is, at least partially, thermally denatured without hydrolytic degradation.
A composite prosthesis comprising:
- (a) a prosthetic non-absorbable fabric having a three-dimensional structure having a thickness separating a first surface and a second surface opposite to said first surface, said first surface having alveoli open to any postsurgical cell colonization;
- and
- (b) at least one film of a crosslinked or gelled but absorbable collagenous material, linked to said prosthetic fabric at least over said second surface, said collagenous material comprising collagen and at least one macromolecular hydrophilic additive chemically unreactive with respect to collagen.
A composite prosthesis comprising:
- (a) a prosthetic non-absorbable fabric having a three-dimensional structure having a thickness separating a first surface and a second surface opposite to said first surface, said first surface having alveoli open to any postsurgical cell colonization;
- and
- (b) at least one film of a crosslinked or gelled but absorbable collagenous material, linked to said prosthetic fabric at least over said second surface, said collagenous material comprising collagen having an helical structure which is, at least partially, thermally denatured without hydrolytic degradation.
A composite prosthesis comprising:
- (a) a prosthetic non-absorbable fabric having a three-dimensional structure having a thickness separating a first surface and a second surface opposite to said first surface, said first surface having alveoli open to any postsurgical cell colonization;
- and
- (b) at least one film of a crosslinked or gelled but absorbable collagenous material, linked to said prosthetic fabric at least over said second surface.
A composite prosthesis comprising:
- (a) a prosthetic non-absorbable fabric having a three-dimensional structure separating a first surface and a second surface opposite to said first surface, said first surface being open to any postsurgical cell colonization;
- and
- (b) at least one film of a crosslinked or gelled but absorbable collagenous material, linked to said prosthetic fabric over said second surface and along said thickness of said prosthetic fabric, by capillary absorption of said collagenous material, before gelling, to the constituent fibers of said prosthetic fabric.
A composite prosthesis comprising:
- (a) a prosthetic non-absorbable fabric having a three-dimensional structure having a thickness separating a first surface and a second surface opposite to said first surface, said first surface presenting alveoli open to any postsurgical colonization, said alveoli passing completely through said prosthetic fabric;
- and
- (b) at least one film of a crosslinked or gelled but absorbable collagenous material, linked to said prosthetic fabric at least over said second surface, said collagenous material comprising collagen and at least one macromolecular hydrophilic additive chemically unreactive with respect to collagen.
A composite prosthesis comprising:
- (a) a prosthetic non-absorbable fabric having a three-dimensional structure having a thickness separating a first surface and a second surface opposite to said first surface, said first surface having alveoli open to any postsurgical cell colonization;
- and
- (b) at least one film of a crosslinked or gelled but absorbable collagenous material, linked to said prosthetic fabric at least over said second surface, the surface of said film opposite to said prosthetic fabric being substantially smooth and non porous.
A composite prosthesis comprising:
- (a) a prosthetic non-absorbable fabric having a three-dimensional structure having a thickness separating a first surface and a second surface opposite to said first surface, said first surface having alveoli open to any postsurgical cell colonization;
- and
- (b) at least one film of a crosslinked or gelled but absorbable collagenous material, linked to said prosthetic fabric at least over said second surface, said film projecting beyond the edges of said prosthetic fabric.
A composite prosthesis comprising:
- (a) a prosthetic non-absorbable fabric having a three-dimensional structure having a thickness separating a first surface and a second surface opposite to said first surface, said first surface having alveoli open to any postsurgical cell colonization;
- and
- (b) at least one film of a crosslinked or gelled but absorbable collagenous material, linked to said prosthetic fabric at least over said second surface, said film being in dehydrated form, and arranged to substantially restore in rehydrated form the initial mechanical properties of said prosthetic fabric.
A composite prosthesis comprising:
- (a) a prosthetic non-absorbable fabric the weave of which determines a three-dimensional structure having a thickness separating a first surface and a second surface opposite to said first surface, said first surface having alveoli open to any postsurgical cell colonization;
- and
- (b) at least one film of a crosslinked collagenous material, linked to said prosthetic fabric at least over said second surface.
A composite prosthesis comprising:
- (a) a prosthetic non-absorbable fabric having a three-dimensional structure having a thickness separating a first surface and a second surface opposite to said first surface, said first surface having alveoli open to any postsurgical cell colonization;
- and
- (b) at least one film of a crosslinked or gelled but absorbable collagenous material, linked to said prosthetic fabric at least over said second surface, said film comprising two superposed thin layers of a collagenous material.
Dependencies are inferred from the claim text.