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US 6,447,765 B1Granted
Use of cytokines and mitogens to inhibit graft versus host disease
AssigneeUniversity of Southern California
InventorDavid A. Horwitz
Life of this patent
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Abstract
The field of the invention is generally related to pharmaceutical agents useful in treating graft-versus-host disease (GVHD) in patients that have received allogenic bone marrow transplants.
Claims4
A method for treating donor cells to ameliorate graft versus host disease in a recipient patient comprising:
- a) removing peripheral blood mononuclear cells (PBMC) from a donor;
- b) treating said cells with a suppressive composition comprising TGF-β for a time sufficient to induce T cell tolerance;
- and
- c) administering said cells to said patient.
1 more element
Dependencies are inferred from the claim text.