Method and apparatus for determination of carbon-halogen compounds and applications thereof
AssigneeSan Diego State University
InventorsClay Marcus Sharts, Vladimir Semenovich Gorelik
Life of this patent
Estimating the term…
Abstract
A method and apparatus for determination of fluoroorganic compounds in liquid, gaseous, or crystalline or amorphous solids is based on the detection of carbon-halogen bonds by laser Raman spectroscopy. The method and apparatus provide a general method for detecting and determination of halooorganic compounds. The method and apparatus are applicable in the pharmaceutical industry, in fluorinated drug research and manufacturing; in the medical and clinical studies of the effects of fluoroorganic compounds; in the environmental and agricultural studies and screening, in the analysis of water, soils and air contaminated with fluoroorganic compounds.
Claims58
A method, comprising:
- providing a sample having a compound including at least one carbon-halogen bond;
- and
- applying a non-continuous light source to detect the at least one carbon halogen bond.
A method, comprising:
- providing at least one fluororganic compound;
- applying a light source to the at least one fluororganic compound
- determining at least one Raman frequency of an acoustic mode of the at least one fluororganic compound;
- determining at least one Raman frequency of an optical mode of the at least one fluororganic compound;
- and
- determining a presence of the at least one fluororganic compound as a function of one of the at least one Raman frequency of the acoustic mode and the at least one Raman frequency of the optical mode.
A method, comprising:
- causing a sample to emit Raman scattered light;
- detecting Raman scattered light indicative of a compound having at least one carbon-halogen bond;
- and
- identifying the compound in the sample.
A method, comprising:
- detecting at least one carbon-fluorine bond in one of a drug, a biologically active compound, and a biologically active substance;
- introducing the one of the drug, the biologically active compound, and the biologically active substance to a biological media;
- and
- determining at least one Raman frequency emitted from one of the drug, the biologically active compound, and the biologically active substance through the biological media.
A method, comprising:
- detecting at least one carbon-fluorine bond in a blood substitute;
- introducing the blood substitute to a biological media;
- and
- determining at least one Raman frequency emitted from the blood substitute through the biological media.
A method, comprising:
- introducing at least one carbon-fluorine bond to one of a compound and a substance;
- detecting the least one carbon-fluorine bond;
- and
- using the at least one carbon-fluorine bond as a tracer.
A method, comprising:
- detecting at least one carbon-fluorine bond in a sample;
- using the at least one carbon-fluorine bond in the sample as a label;
- determining at least one concentration level for one of water, soil, and air samples using the label.
A method, comprising:
- introducing at least one carbon-fluorine bond to a drug;
- detecting the at least one carbon-fluorine bond in the drug;
- and
- using the at least one carbon-fluorine bond as a label.
A method, comprising:
- exposing a sample to a pulsed metal-vapor laser having a wavelength that induces Raman scattered light emission from at least one carbon-fluorine bond;
- time-gating the pulsed metal-vapor laser;
- and
- detecting Raman scattered light emitted from a compound in the sample, wherein detection of characteristic Raman scattered light is indicative of at least one carbon-fluorine bond of the compound.
Dependencies are inferred from the claim text.