System and method for molecular sample measurement
AssigneeCorning Applied Technologies Corporation
InventorsPaul Melman, Marvin Tabasky
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Abstract
A system for aligning the optical components of a chemical analysis system in which capillaries or optical fibers are supported by a substrate. The system provides for alignment of elements of an electrophoresis system in an efficient high sampling rate capability. The system provides multiple sources, such as lasers or LEDs that are optically coupled to each capillary or channel. Multi-analyte capability, a variety of analysis modes and DNA sequencing operations are applications of systems using a plurality of lasers per channel.
Claims18
A channel fluorescense analysis system comprising:
- a plurality of light sources which emit at a plurality of different wavelengths;
- a driver circuit connected to each light source that modulates the light emitted by each light source;
- an optical coupler;
- a plurality of channels, each channel positioned to receive light through the optical coupler from at least two of the light sources, each channel containing a material that fluoresces in response to the received light;
- and
- a detector system optically coupled to the plurality of channels.
A channel fluorescence analysis system comprising:
- a light source which emits a plurality of wavelengths;
- a driver circuit connected to the light source that modulates the light emitted by the light source;
- an optical coupler;
- an array of channels, each channel positioned to receive light of different wavelengths through the optical coupler from the light source, the channels containing a material that fluoresces in response to the light;
- and
- a detector system optically coupled to the array of channels.
A method for synchronous detection of a capillary gel electrophoresis system comprising:
- connecting a plurality of semiconductor lasers which emit a plurality of wavelengths to a plurality of capillaries using a fiber optic delivery system;
- modulating the semiconductor lasers;
- and
- collecting emitted fluorescence from the capillaries using a fiber optic collection system.
Dependencies are inferred from the claim text.