Process for the production of enantiomerically pure or optically enriched sertraline-tetralone using continuous chromatography
AssigneeChiral Technologies Europe SAS
InventorsOliver Dapremont, Fiona Geiser, Tong Zhang, Subramanian S. Guhan, Robert M. Guinn, George J. Quallich
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Abstract
A process for the production of enantiomerically pure or optically enriched sertraline-tetralone from a mixture containing two enantiomers using continuous chuomatography. The chromatography comprises a liquid mobile phase comprising at least one polar solvent and a solid chiral stationary phase comprising a derivatized polysaccharide that is selected from amylosic, cellulosic, chitosan, xylan, curdlan, and inulan class of polysaccharide.
Claims21
A process for chromatographically resolving enantiomerically pure or optically enriched sertraline-tetralone from a mixture containing two enantiomers using continuous chromatography, the continuous chromatography comprising a liquid mobile phase comprising a least one polar solvent and a solid chiral stationary phase comprising a derivatized polysaccharide that is selected from the amylosic, cellulosic, chitosan, xylan, curdlan, dextran, and inulan class of polysaccharides.
A process for chromatographically resolving enantiomerically pure or optically enriched sertraline tetralone from a mixture containing two enantiomers using single column high performance chromatography comprising a liquid mobile phase comprising at least one polar solvent and a solid chiral phase comprising a derivatized polysaccharide that is selected from the amylosic, cellulosic, chitosan, xylan, curdlan, dextran and inulan class of polysaccharides.
A process for the production of enantiomerically pure or optically enriched sertraline-tetralone from a mixture containing tyro enanflomers using simulated moving bed chromatography, the moving bed chromatography comprising a liquid mobile phase comprising a least one polar solvent and a solid chiral stationary phase comprising a derivatized polysaccharide that is selected from the amylosic, cellulosic, chitosan, xylan, curdlan, dextran, and inulan class of polysaccharides.
A process for resolving enantiomerically pure or optically enriched sertraline-tetralone from a mixture containing two enantiomers using chromatography comprising using a mobile phase comprising said mixture and at least one polar solvent and a solid chiral stationary phase comprising a derivatized polysaccharide immobilized on a substrate wherein said derivatized polysaccharide is selected from the group consisting of amylosic, cellulosic, chitosan, xylan, curdlan, dextran and inulan class polysaccharides.
A process for resolving enantiomerically pure or optically enriched sertraline-tetralone from a mixture containing two enantiomers using chromatography comprising using a mobile phase comprising said mixture and at least one polar solvent and a solid chiral stationary phase comprising a derivatized polysaccharide immobilized on a substrate wherein said derivatized polysaccharide is selected from the group consisting of amylosic, cellulosic, chitosan, xylan, curdlan, and inulan class polysacchlarides.
Dependencies are inferred from the claim text.