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US 6,444,851 B1Granted
Process for the preparation of Midodrine
AssigneeChemagis Ltd.
InventorsMichael Brand, Ronit Chen, Deby Yigal, Joseph Kaspi
Life of this patent
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Abstract
The invention provides a process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide of the formula 1 by hydrogenolysis of substituted 2-dibenzylamino-N-[2-(2′,5′-dimethoxyphenyl)-2-hydroxy-ethyl]acetamide having the formula (5), wherein Ar and Ar′ are aryl groups,
Claims9
A process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide HCl of the formula 1 by hydrogenolysis of substituted 2-dibenzylamino-N-[2-(2′,5′-dimethoxyphenyl)-2-hydroxyethyl]acetamide having the formula (5), wherein Ar and Ar′ are aryl groups,
Dependencies are inferred from the claim text.