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US 6,444,832 B1Granted
Amino alcohol derivatives, method of producing said derivatives and medicaments containing them
OwnerAngelika Esswein, Lothar Kling +2inventors
InventorsAngelika Esswein, Lothar Kling, Ulrike Leser, Walter-Gunar Friebe
Life of this patent
Estimating the term…
Abstract
Compounds of formula I in which R1 denotes hydrogen or methyl R2 denotes lower straight-chained or branched alkyl with 1 to 10 carbon atoms R3 denotes hydrogen or lower alkyl n denotes 0-12 R4 denotes alkyl, alkenyl or alkinyl with 6 to 24 carbon atoms, processes for the production thereof as well as pharmaceutical agents containing these compounds for the treatment of osteoporosis.
Claims8
A process for the production of compounds of formula I
- in which
- R1 denotes hydrogen or methyl
- R2 denotes lower straight-chained or branched alkyl with 1 to 10 carbon atoms, provided that when R2 denotes methyl or isobutyl, —(CH2)n—R4 is not (all-cis-4,7,10,13)-octadecatetraenyl or an unbrancehed chain with 14 carbon atoms
- R3 denotes hydrogen or lower alkyl
- n denotes 0-12
- R4 denotes alkyl, alkenyl or alkinyl with 6 to 24 carbon atoms, provided that when R4 denotes alkyl, —(CH2)n—R4 is not an unbranched alkyl chain with 8, 10, 12, 14 or 16 carbon atoms
- as well as pharmacologically acceptable salts and optical isomers thereof;
- said process comprising reacting a compound of formula II
- in which R1, R2, and R3 have the above meanings either with
- (a) a compound of formula III
- in which R4 and n have the above meanings and X represents an activating group or
- (b) with a compound of formula IV R4—(CH2)n+1—CN (IV) in which R4 and n have the above meanings.
9 more elements
Compounds of formula I
- in which
- R1=hydrogen or methyl
- R2=lower straight-chained or branched alkyl with 1 to 10 carbon atoms, with the proviso that when R2 is isopropyl, then —(CH2)n—R4 may not be an unbranched chain with 6 or 10 carbon atoms, when R2 is methyl, then R1 is hydrogen, and (CH2)4—R4 may not be (all-cis-3, 6, 9, 12)-octadecatetranenyl, (all-cis-4,7,10,13)-octadecatetraene or an unbranched chain with 14 carbon atoms, and when R2 is isobutyl, then (CH2)4—R4 may not be (all-cis-4,7,10,13)-octadecatetraene,
- R3=hydrogen
- n=0-12
- R4=alkyl, alkenyl or alkinyl with 6 to 24 carbon atoms, with the proviso that when R4 is alkyl, —(CH2)4—R4 may not be an unbranched alkyl chain with 6, 8, 10, 12 14 or 16 carbon atoms,
- as well as pharmacologically acceptable salts and optical isomers thereof.
4 more elements
A pharmaceutical compostion containing at least one compound of formula I
- in which
- R1 denotes hydrogen or methyl
- R2 denotes lower straight-chained or branched alkyl with 1 to 10 carbon atoms, with the proviso that when R2 is isopropyl, then —(CH2)n—R4 may not be an unbranched chain with 6 or 10 carbon atoms, and when R2 is methyl, then R1 is hydrogen, and —(CH2)4—R4 may not be (all-cis-3, 6, 9, 12)-octadecatetranenyl, or an unbranched chain with 14 carbon atoms
- R3 denotes hydrogen [or lower alkyl]
- n denotes 0-12
- R4 denotes alkyl, alkenyl or alkinty with 6 to 24 carbon atoms, which the proviso that when R4 is alkyl, then —(CH2)4—R4 may not be an unbranched alkyl chain with 6, 8, 10, 12 14 or 16 carbon atoms, in addition to common carrier and auxiliary substances.
3 more elements
Dependencies are inferred from the claim text.