Thrombin inhibitors

A compound of formula I

• or a salt thereof with a physiologically tolerated acid, or a stereoisomers thereof, wherein
• R1:
• H, C1-4-alkyl;
• R2:
• H, C1-4-alkyl or phenyl;
• in which the substituents have the following meanings:
• m:
• 0 or 1,
• n:
• 2 or 3,
• R3:
• H, C1-12-alkyl, aryl-C1-4-alkyl, R19OOC—C1-6-alkyl (R19═H, C1-4-alkyl, benzyl), HO3S—C1-3-alkyl, C1-7-alkyl-OOC, benzyl-OOC, or R20R21N—CO— (R20 and R21 are identical or different and are H, C1-6-alkyl, aryl, aryl-C1-4-alkyl, R19OOC—C1-4-alkyl or R19—NH—CO—C1-4-alkyl, or R20 and R21 are together a —(CH2)3-6— group),
• R4:
• H, C1-12-alkyl or aryl-C1-4-alkyl,
• R5:
• H or C1-4-alkyl,
• R6:
• C3-8-cycloalkyl, which is unsubstituted or carries up to 4 C1-4-alkyl and/or CH3O groups, and one or more methylene group(s) can be replaced by —O—, or adamantyl, norbornyl, 1-decalinyl, 1-tetralinyl, 2-tetralinyl, 1-indanyl, 2-indanyl, dibenzosuberyl, which is unsubstituted or monosubstituted on one or both aromatic rings, diphenylmethyl which is unsubstituted or monosubstituted on one or both rings, dicyclohexylmethyl, phenyl-C(CH3)2—, C1-4-alkyl-C≡C—, R22O—C(R23R24)—, where R22 is H or C1-4-alkyl, and R23 and R24 are H, C1-4-alkyl, HO—C1-3-alkyl or phenyl, phenyl which is unsubstituted or substituted by up to 3 identical or different radicals selected from the group of C1-4-alkyl, CF3, C1-4-alkoxy, F and Cl, R25R26CH where R25 is C1-6-alkyl, and R26 is H or C1-6-alkyl,
• R7:
• H, c1-12-alkyl, C1-20-alkyl-CO, R19OOC—C1-4-alkyl, R19OOC—C1-4-alkyl-CO, R20R21N—CO, HO3S—C1-4-alkyl, or the acyl radical of a natural or unnatural bile acid,
• R8:
• C3-8-cycloalkyl, where the aliphatic rings are unsubstituted or carry up to 4 C1-4-alkyl and/or CH3O groups, and one or more methylene group(s) can be replaced by —O—, or adamantyl, norbornyl, 1-decalinyl, 1-tetralinyl, 2-tetralinyl, 1-indanyl, 2-indanyl, dibenzosuberyl which is unsubstituted or monosubstituted on one or both aromatic rings, diphenylmethyl which is unsubstituted or monosubstituted on one or both rings, dicyclohexylmethyl, phenyl-C(CH3)2—, C1-4-alkyl-C≡C, R22O—C(R23R24)—, where R22 is H or C1-4-alkyl, and R23 and R24 are H, C1-4-alkyl, HO—C1-3-alkyl or phenyl, phenyl which is unsubstituted or substituted by up to 3 identical or different radicals from the group of F, Cl, C1-4-alkyl, C1-4-alkoxy or CF3, R25R26CH—, where R25 is C1-6-alkyl, and R26 is H or C1-6-alkyl,
• R9:
• H, C1-4-alkyl, phenyl or C5-6-cycloalkyl (R9 can in accordance with formula IIc be a substituent on all ring positions apart from positions 1 and 2),
• wherein
• q:
• 1 or 2
• r:
• 3 or 4
• Y:
• a methylene group, an ethylene group in which the ring resulting therefrom is unsubstituted or carries in position 4 a hydroxyl or C1-4-alkoxy group, —CH2—S—, —CH2—O—, —CH═CH— or a propylene group, in which the ring resulting therefrom is unsubstituted or carries on the carbon in position 3 and/or 4 a C1-4-alkyl group and in which a CH2 group optionally is replaced by —O—,
• R11:
• H or C3-8-cycloalkyl,
• R12:
• H, C1-6-alkyl or C5-6-cycloalkyl, phenyl,
• wherein
• R13, R14 and R15, which are identical or different, are H, R30—O— or R30OOC—, where R30 is H, C1-6-alkyl and C3-6—cy-cloalkyl, where R13, R14 and R15 are not all hydrogen, or
• R13 and R14 together are a chain —CH2—CH2—CH2—CH2—, —CH2—CH2—CH2—, —O—CH2—O— or —CH═CH—CH═CH—;
• and
• R29:
• H or C1-4-alkyl, C1-4-alkoxy or C1-4-alkoxy-CO.