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US 6,444,811 B1Granted
Pyrazinones, compositions containing such compounds and methods of use
AssigneeMerck Frosst Canada, Inc.
InventorsYongxin Han, Andre Giroux, Robert Zamboni, Daniel J. McKay, Christopher I. Bayly, Erich L. Grimm, John Colucci
Life of this patent
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Abstract
Compounds represented by formula I: as well as pharmaceutically acceptable salts, esters, N-oxides and hydrates thereof are disclosed. Pharmaceutical compositions and methods of use are also included. The compounds are active against the caspase-3 enzyme, and thus are useful to treat fin caspase-3 mediated diseases and conditions.
Claims1
A compound in accordance with table 1:
- TABLE 1 Com- pound Number 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105
- or a pharmaceutically acceptable salt, hydrate, N-oxide or ester thereof, said ester formed at the carboxy group shown in the compounds.
Dependencies are inferred from the claim text.