Back to results
US 6,444,790 B1Granted
Peptidoglycan recognition proteins
AssigneeHuman Genome Sciences, Inc.
InventorsPaul E. Young, Steven M. Ruben, Craig A. Rosen, Henrik S. Olsen
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeHuman Genome Sciences, Inc.
InventorsPaul E. Young, Steven M. Ruben, Craig A. Rosen, Henrik S. Olsen
Estimating the term…
The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
An isolated protein comprising amino acid residues 52 to 135 of SEQ ID NO:4.
An isolated protein comprising the amino acid sequence of the secreted portion of the polypeptide encoded by the cDNA contained in ATCC Deposit No. 203563.
An isolated protein comprising a polypeptide sequence which is at least 90% identical to amino acid residues 18 to 368 of SEQ ID NO:4, wherein said isolated protein possesses peptidoglycan binding activity.
An isolated protein comprising a polypeptide sequence which is at least 90% identical to amino acid residues 52 to 135 of SEQ ID NO:4, wherein said isolated protein possesses peptidoglycan binding activity.
An isolated protein comprising a polypeptide sequence which is at least 90% identical to the secreted portion of the polypeptide encoded by the cDNA contained in ATCC Deposit No. 203563, wherein said isolated protein possesses peptidoglycan binding activity.
An isolated protein comprising at least 30 contiguous amino acid residues of amino acid residues 52 to 135 of SEQ ID NO:4, wherein said isolated protein possesses peptidoglycan binding activity.
An isolated protein comprising at least 30 contiguous amino acid residues of amino acid residues 18 to 368 of SEQ ID NO:4, wherein said isolated protein possesses peptidoglycan binding activity.
An isolated protein comprising at least 30 contiguous amino acid residues of the secreted portion of the polypeptide encoded by the cDNA contained in ATCC Deposit No. 203563, wherein said isolated protein possesses peptidoglycan binding activity.
An isolated protein comprising at least 30 contiguous amino acid residues of amino acid residues 1 to 368 of SEQ ID NO:4, wherein said isolated protein possesses peptidoglycan binding activity.
An isolated protein comprising at least 30 contiguous amino acid residues of the complete polypeptide encoded by the cDNA contained in ATCC Deposit No. 203563, wherein said isolated protein possesses peptidoglycan binding activity.
An isolated protein comprising at least 30 contiguous amino acid residues of amino acid residues 18 to 368 of SEQ ID NO:4, wherein said isolated protein possesses peptidoglycan binding activity.
An isolated protein comprising a polypeptide sequence selected from the group consisting of:
Dependencies are inferred from the claim text.