Use of certain fatty acid/amino acid soaps to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions
AssigneeAlcon Manufacturing, Ltd.
InventorsErnesto J. Castillo, Steven Gerson, Wesley Wehsin Han
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Abstract
Fatty acid/amino acid soaps are used to enhance antimicrobial effectiveness in topically administrable pharmaceutical compositions containing at least one active ingredient, a cationic preservative and an anionic polyelectrolyte, such as a carboxyvinyl polymer, xanthan gum, polystyrene sulfonic acid polymer or cationic exchange resin.
Claims17
A method of improving or enhancing the antimicrobial efficacy of a topically administrable pharmaceutical composition comprising a cationic antimicrobial, an anionic polyelectrolyte and an active ingredient, wherein the method comprises adding to the composition an antimicrobial-enhancing amount of a fatty acid/amino acid soap having a fatty acid component selected from the group consisting of C8-C24 fatty acids and an amino acid component selected from the group consisting of lysine and arginine, wherein the fatty acid component and the amino acid component are ionically associated in the soap, and wherein the antimicrobial-enhancing amount is from about 0.001 to about 1%, provided that the composition does not contain a phospholipid.
A topically administrable pharmaceutical composition comprising a cationic antimicrobial, an anionic polyelectrolyte, an active ingredient, and an antimicrobial-enhancing amount of a fatty acid/amino acid soap having a fatty acid component selected from the group consisting of C8-C24 fatty acids and an amino acid component selected from the group consisting of lysine and arginine, wherein the fatty acid component and the amino acid component are ionically associated in the soap, and wherein the antimicrobial-enhancing amount is from about 0.001 to about 1%, provided that the composition does not contain a phospholipid.
Dependencies are inferred from the claim text.