Heteroethylene compounds and pharmaceutical and cosmetic compositions containing same

Heteroethynylenic compounds, corresponding to formula (I) below:

• in which:
• R1 represents:
• (i) a —CH3 radical
• (ii) a radical —CH2—O—R5
• (iii) radical —COR6
• R5 and R6 having the meanings given below,
• X represents:
• O, Se, S(O)n, n being 0, 1 or 2,
• Y represents a divalent radical which has the formula:
• R7, R8, R9 and R10 having the meanings given below,
• R2 and R3, taken together, form, with the adjacent aromatic ring, a 5- or 6-membered ring optionally substituted with methyl groups and/or optionally interrupted by an oxygen or sulphur atom,
• or R2 and R3 independently, which may be identical or different, can represent:
• a) a hydrogen atom,
• b) a radical comprising
• tert-butyl,
• 1-methylcyclohexyl, or
• 1-adamantyl,
• c) a radical —OR11
• d) a polyether radical
• e) a halogen atom
• R11 having the meaning given below, it being understood that at least one of the substituents R2 and R3 represents (b),
• R4 represents a hydrogen atom, a lower alkyl radical, a radical OR12, a polyether radical, a radical COR13 or a halogen atom,
• R12 and R13 having the meanings given below,
• R′4 represents a hydrogen atom or a halogen atom,
• R5 represents a hydrogen atom or a lower alkyl radical,
• R6 represents:
• (i) a hydrogen atom
• (ii) a lower alkyl radical
• (iii) a radical OR14
• R14 having the meaning given below,
• (iv) a radical of formula
• R′ and R″ having the meanings given below,
• R7, R8, R9 and R10, which may be identical or different, represent a hydrogen atom, a lower alkyl radical or an aryl radical,
• R11 and R12, which may be identical or different, represent a hydrogen atom, a lower alkyl radical, an optionally substituted aryl radical, an optionally substituted aralkyl radical, a monohydroxyalkyl or polyhydroxyalkyl radical or a lower acyl radical,
• R13 represents a lower alkyl radical, a radical OR15 or a radical
• R15, R′ and R″ having the meanings given below,
• R14 and R15 which may be identical or different, represent a hydrogen atom, a lower alkyl radical, an aryl radical, an optionally substituted aralkyl radical, a monohydroxyalkyl radical or a polyhydroxyalkyl radical,
• R′ and R″, which may be identical or different, represent a hydrogen atom, a lower alkyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl radical or an amino acid residue, or alternatively, taken together with the nitrogen atom, form a heterocycle,
• as well as the salts thereof and the optical and geometrical isomers thereof.