1,3-disubstituted ureas as ACAT inhibitors, and method of preparing thereof

A method of inhibiting the effect on the acyl co-enzyme A:

• cholesterol acyltransferase (ACAT) enzyme comprising administering to a patient in need of said inhibiting effect, a 1,3-disubstituted ureas of general formula I
• wherein R1 is 2-fluorophenyl, 2,4-difluorophenyl, 2,5-difluorophenyl, 2,6-difluorophenyl, 2-chlorophenyl, 2,3-dichlorophenyl, 2,6-dichlorophenyl, 3,5-dichlorophenyl, 2-methylphenyl, 4-methylphenyl, 2,4-dimethylphenyl, 2,6-dimethylphenyl, 3,5-dimethylphenyl, 2,6-di(methylethyl)phenyl, 2-trifluoromethylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 1-naphthyl, 2-naphthyl, or 1-adamantyl, R2 is nitro and X═O;
• or
• R1 is 4-nitrophenyl, 2-fluorophenyl, 4-fluorophenyl, 2,4-difluorophenyl, 2,5-difluorophenyl, 2,6-difluorophenyl, 2-chlorophenyl, 4-chlorophenyl, 2,3-dichlorophenyl, 2,4-dichlorophenyl, 2,6-dichlorophenyl, 3,4-dichlorophenyl, 3,5-dichlorophenyl, 2-methylphenyl, 4-methylphenyl, 2,4-dimethylphenyl, 2,6-dimethylphenyl, 3,5-dimethylphenyl, 2,6-di(methylethyl)phenyl, 2-trifluoromethylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 1-naphthyl, 2-naphthyl, or 1-adamantyl, R2 is nitro, and X═S;
• or
• R1 is 2,4-difluorophenyl, 2,3-dichlorophenyl, 2,6-dimethylphenyl, or 2,6-di(methylethyl)-phenyl, R2 is amino, and X═O, S.