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US 6,444,683 B2Granted
17-azolyl steroids useful as androgen synthesis inhibitors
AssigneeUniversity of Maryland at Baltimore
InventorsAngela Brodie, Vincent C. O. Njar
Life of this patent
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Abstract
Androgen synthesis inhibitors, as well as methods for the use of the same to reduce plasma levels of testosterone and/or dyhydrotestosterone, and to treat prostate cancer and benign prostatic hypertrophy, are disclosed.
Claims10
A compound of Formula (I):
- wherein X represents the residue of the A, B and C rings of an aza steroid consisting of a 4-en-3-one or 5-en-3β-ol system;
- Az represents an azole ring attached to C-17 of the aza steroid via a hetero nitrogen atom;
- and R1 and R2 represent a hydrogen atom or together represent a double bond.
Dependencies are inferred from the claim text.