Back to results
US 6,444,682 B1Granted
Base analogues
AssigneeNycomed Amersham plc
InventorsAdrian Christopher Simmonds, Alan Hamilton, Clifford Smith, David Loakes, Daniel Brown, Fergal Hill, Shiv Kumar, Satyam Nampalli, Mark McDougall
Life of this patent
Estimating the term…
Abstract
Nucleotide or base analogues having structure (3) or (4) wherein X═O or NH or S and each R6 is independently H or alkyl or alkenyl or alkoxy or aryl or a reporter moiety.
Claims14
A compound having the structure selected from the group consisting of
- where X═O or NH or S
- each R6 is independently H or alkyl or alkenyl or alkoxy or aryl or a reporter moiety,
- provided that
- in structure (3), when X is O, then at least one R6 is a reporter moiety which is a reactive group or signal moiety or solid surface joined to the remainder of the molecule by a linker of at least 3 chain atoms,
- in structure (3), when X is NH, then at least one R6 is a reporter moiety,
- and wherein the compound is a nucleoside or nucleoside analogue wherein Q is
- where Z is O,
- R1, R2, R3 and R4 are the same or different and each is H or OH
- R5 is mono-, di-, or tri-phosphate,
- or one of R2 and R5 is a phosphoramidite or other group for incorporation in a polynucleotide chain.
7 more elements
Dependencies are inferred from the claim text.