5-membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists

A compound of the formula (I):

• or the pharmaceutically acceptable salts thereof wherein
• A is independently halo;
• Y1 is —(CH2)m—, C(O) or S(O);
• Y2 is N or CH;
• R1 and R2 are independently C1-4 alkyl;
• R3 is selected from the following:
• (a) —(CH2)p—C3-7 cycloalkyl, the cycloalkyl moiety being optionally substituted with one, two or three substituents selected from cyano, amino-C1-4 alkyl-, C1-4 alkylamino-C1-4 alkyl-, C1-3 alkyl-carbonylamino-C1-4 alkyl-, C1-4 alkylsulfonylamino-C1-4 alkyl, amino, 2-oxopyrrolidinyl, C4-7 cycloalkylamino-C1-4 alkyl, di-C1-4 alkylamino-C1-4 alkyl-, hydroxyl, carbamoyl, C1-3 alkylcarbonyl(C1-4 alkyl)amino, C1-4 alkylcarbonyl(C1-4 alkyl)amino-C1-4 alkyl, di-C1-4 alkylamino, pyrrolidinyl-C1-4 alkyl, 2-oxopyrrolidinyl-C1-4 alkyl and di-C1-4 alkylamino-C1-4 alkyl;
• (b) —C5-7 alkyl optionally substituted with one or two substituents selected from 2-oxopyrrolidinyl, C1-3 alkylsuflonylamino, cyano, C1-3 alkylcarbonylamino, 1,1-dioxoisothiazolinyl, 2-oxo-1,3-oxazolidinyl, amino, C1-4 alkylamino, morpholinylcarbonyl, morpholino, C1-3alkyl-2-oxopyrrolidinyl, piperidinyl and 2-oxo-piperidinyl;
• (c) —C1-4 alkyl substituted with one or two substituents selected from 2-oxopyrrolidinyl, C1-3 alkylsuflonylamino, cyano, C1-3 alkylcarbonylamino, 1,1-dioxoisothiazolinyl, 2-oxo-1,3-oxazolidinyl, morpholino, C1-3alkyl-2-oxopyrrolidinyl, piperidinyl and 2-oxo-piperidinyl;
• and
• (d) C7-9 bicycloalkyl optionally substitued with di-C1-4 alkylamino and oxopyrrolidinyl;
• R4 is thiazolyl, imidazolyl or oxazolyl, the thiazolyl, imidazolyl or oxazolyl being optionally substituted with one or two substituents independently selected from C1-4 alkyl and halo;
• X is S, —NH, —N—C1-4 alkyl or 0;
• R5 is hydrogen or C1-4 alkyl;
• R6 is C1-4 alkyl or halo;
• m is 0, 1 or 2;
• n is 0, 1, 2, 3, 4 or 5;
• and
• p is 0, 1, 2, 3, 4, 5 or 6.