4-alkyl and 4-cycloalkyl derivatives of dihydropyridine NPY antagonists

A compound of Formula (I) or its pharmaceutically acceptable acid addition salts or hydrates thereof

• wherein
• R1 and R4 are independently selected from lower alkyl and CO2R5, cyano and
• where R5 is a lower alkyl;
• R2 and R3 are independently selected from hydrogen, cyano and lower alkyl;
• A is lower alkyl or C5-6cycloalkyl;
• X is —NH— or a covalent bond;
• n is an integer selected from 2 to 5;
• in which R6 and R7 are independently selected from lower alkyl and lower alkanol;
• the solid and broken line denote a single or double covalent bond;
• R8 is selected from hydrogen, lower alkyl, —CO2R1, —(CH2)mR10, hydroxy, cyano, —(CH2)nNR11R12, wherein
• m is zero or an integer from 1 to 3;
• R10 is C3-7 cycloalkyl, naphthyl,
• with R13 being lower alkyl, lower alkenyl, C3-7 cycloalkyl, lower alkoxy, hydrogen, halogen, hydroxy, dialkylamino, phenoxy, amino, —NHCOR1, —CO2R1, NO2, trifluoromethyl, phenyl, and R11 and R12 are lower alkyl or are taken together as a C3-5 alkylene chain or an ethyl-oxy-ethyl chain.