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US 6,444,674 B1Granted
Substituted pyrimidine compounds and the use thereof
AssigneeAbbott Laboratories
InventorsBeate Hellendahl, Annegret Lansky, Rainer Munschauer, Siegfried Bialojan, Liliane Unger, Hans-Jürgen Teschendorf, Karsten Wicke, Karla Drescher
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Abstract
The present invention relates to the use of pyrimidine compounds of the following formula: where R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
Claims15
A pyrimidine compound of formula I
- wherein
- A is C2-C15-alkylene which is interrupted by, or which is bonded to the pyrimidine ring through, a radical NR4,
- B is
- R1, R2, R3 are, independently of one another, H, halogen, OR4, NR4R5, SR4 CF3, CN, CO2R4 or C1-C8-alkyl which is unsubstituted or substituted by OH, OC1-C8-alkyl or halogen,
- R4 is H, C1-C8-alkyl which is unsubstituted or substituted by OH, OC1-C8-alkyl or halogen,
- R5 has the meanings indicated for R4 or is COR4 or CO2R4,
- Ar is pyridyl, pyrimidyl, triazinyl, naphthyl or quinolinyl, where Ar may carry from one to four substituents selected from the group consisting of OR5, C1-C8-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, halogen, CN, CO2R4, NO2, SO2R4, SO3R4, NR4R5, SO2NR4R5, SR4, CF3, CHF2, pyrrolyl and pyrrolidinyl,
- or a salt thereof with a physiologically tolerated acid.
5 more elements
Dependencies are inferred from the claim text.