Methods for treating certain diseases using naaladase inhibitors
AssigneeGuilford Pharmaceuticals Inc.
InventorsBarbara S. Slusher, Xi-Chun May Lu, Krystyna Wozniak
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Abstract
The present invention relates to methods of using NAALADase inhibitors to regulate TGF-β and to treat neurodegenerative disorders, extracellular matrix formation disorders, cell-growth related diseases, infectious diseases, immune related diseases, epithelial tissue scarring, collagen vascular diseases, fibroproliferative disorders, connective tissue disorders, inflammatory diseases, respiratory distress syndrome and infertility.
Claims25
A method of treating a disease or condition in a mammal, which comprises:
- administering an effective amount of a NAALADase inhibitor to the mammal in need of such treatment, wherein the disease or condition is epithelial tissue scarring, a collagen vascular disease, a fibroproliferative disorder, a connective tissue disorder, or a respiratory distress syndrome.
A method of treating a disease or condition in a mammal, which comprises administering an effective amount of a NAALADase inhibitor to the mammal in need of such treatment, wherein the disease or condition is an infectious disease, provided that the disease or condition is not herpes.
A method of treating a disease or condition in a mammal, which comprises administering an effective amount of a NAALADase inhibitor to the mammal in need of such treatment, wherein the disease or condition is infertility.
Dependencies are inferred from the claim text.