Back to results
US 6,444,650 B1Granted
Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
AssigneesGeron Corporation, University Technology Corporation
InventorsThomas R. Cech, Joachim Lingner, Toru Nakamura, Karen B. Chapman, Gregg B. Morin, Calvin B. Harley, William H. Andrews
Life of this patent
Estimating the term…
Abstract
The present invention provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cancer.
Claims14
An isolated antisense oligonucleotide that hybridizes to a target DNA having the nucleotide sequence of SEQ. ID NO:1 at 5° C. to 25° C. below Tm in aqueous solution at 1 M NaCl;
- wherein Tm is the melting temperature of a complementary oligonucleotide hybridized to the target DNA in aqueous solution at 1 M NaCl, wherein the complementary oligonucleotide is exactly complementary to SEQ. ID NO:1 and the same length as the antisense oligonucleotide;
- and
- wherein hybridization of the antisense oligonucleotide to an mRNA encoding hTRT (SEQ. ID NO:1.)inhibits expression of the mRNA.
Dependencies are inferred from the claim text.