Use of angiotensin II type 2 receptor agonists in tissue repair
AssigneeUniversity of Southern California
InventorsKathleen Elizabeth Rodgers, Gere Stodder Dizerega
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Abstract
Angiotensin II Type 2 receptor agonists (AT2 receptor subtype agonists) are useful in accelerating wound healing. These compounds form the basis of compositions useful for accelerating wound healing, in which the active agent is present in an amount effective to accelerate wound healing. Preferably, the compositions are in the form of matrical or micellar solutions.
Claims12
A method of accelerating wound healing, comprising applying to a wound an amount effective to accelerate wound healing of an active agents, wherein the active agent comprises a sequence of the formula
- R1—R2—R3—R4—R5—R6—R7—R8
- wherein R1 is selected from the group consisting of Asp, Glu, Asn. Acpc, Ala, Me2Gly, Pro, Bet, Glu(NH2), Gly, Asp(NH2), and Suc;
- R2 is selected from the group consisting of Arg, Lys, Ala, Orn Ser(Ac), Sar, D-Arg, and D-Lys;
- R3 is selected from the group consisting of Val, Ala, Leu, Ile, Gly, Pro, Aib, Acpc, and Tyr;
- R4 is selected from the group consisting of Tyr, Thr, Ser, and azaTyr;
- R5 is selected from the group consisting of Ile, Ala, Leu, Val, and Gly;
- R6 is p-NH2-Phe;
- R7 is Pro or Ala;
- R8 is selected from the group consisting of Phe, Phe(Br), Ile, and Tyr;
- and
- wherein the active agent is not AII.
A composition for accelerating wound healing, comprising a suitable carrier or diluent and an amount effective to accelerate wound healing of at least one active agent, wherein the active agent comprises the formula
- R1—R2—R3—R4—R5—R6—R7—R8
- wherein R1 is selected from the group consisting of Asp, GAu, Asn, Acpc, Ala, Me2Gly Pro, Bet, Glu(NH2), Gly, Asp(NH2), and Suc;
- R2 is selected from the group consisting of Arl, Lys, Ala, Orn, Ser(Ac), Sar, D-Arg, and D-Lys;
- R3 is selected from the group consisting of Val, Ala, Leu, Ile, Gly, Pro, Aib, Acpc, and Tyr;
- R4 is selected from the group consisting of Tyr, Thr, Ser, and azaTyr;
- R5 is selected from the group consisting of Ile, Ala, Leu, Val, and Gly;
- R6 is p-NH2-Phe;
- R7 is Pro or Ala;
- R8 is selected from the group consisting of Phe, Phe(Br), Ile, and Tyr;
- and
- wherein the active agent is not AII.
Dependencies are inferred from the claim text.