Methods of using inhibitors of cyclophilin rotamase activity to affect neurological activity
AssigneesGuilford Pharmaceuticals Inc., The Johns Hopkins University School of Medicine
InventorsJoseph P. Steiner, Gregory S. Hamilton, Solomon H. Snyder
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Abstract
This invention relates to the method of using neurotrophic cyclophilin inhibitor compounds having an affinity for cyclophilin-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
Claims6
A method of effecting a neurological activity in an animal comprising administering an effective amount of a cyclophilin inhibitor compound, the cyclophilin inhibitor compound having an affinity for a cyclophilin-type immunophilin, wherein the cyclophilin-type immunophilin exhibits rotamase activity and the cyclophilin inhibitor compound inhibits the rotamase activity of the cyclophilin-type immunophilin with an apparent Ki of less than that of cyclosporin A.
A method of effecting a neurological activity in an animal comprising administering an effective amount of a non-immunosuppressive cyclophilin inhibitor compound, the cyclophilin inhibitor compound having an affinity for a cyclophilin-type immunophilin, wherein the cyclophilin-type immunophilin exhibits rotamase activity and the non-immunosuppressive cyclophilin inhibitor compound inhibits the rotamase activity of the cyclophilin-type immunophilin.
Dependencies are inferred from the claim text.