Methods of increasing myotube formation or survival or muscle cell mitogenesis, differentiation or survival using a neuregulin
AssigneeCeNes Pharmaceuticals, Inc.
InventorsRobert Sklar, Mark Marchionni, David I. Gwynne
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Abstract
The invention relates to methods of treating diseases and disorders of the muscle tissues in a vertebrate by the administration of compounds which bind the p185erbB2 receptor. These compounds are found to cause increased differentiation and survival of cardiac, skeletal and smooth muscle.
Claims40
A method of stimulating myogenesis of a muscle cell in a mammal in need thereof, said method comprising administering to said mammal an effective amount of a neuregulin polypeptide with p185erbB2 protein binding activity.
A method of increasing the myotube formation, myotube survival, muscle cell mitogenesis, muscle cell differentiation, or muscle cell survival in a mammal, said method comprising administering to said mammal an effective amount of a neuregulin polypeptide, said polypeptide being a polypeptide with p185erbB2 protein binding activity.
Dependencies are inferred from the claim text.