Antisense modulation of helicase-moi expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsDonna T. Ward, Andrew T. Watt
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of helicase-moi. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding helicase-moi. Methods of using these compounds for modulation of helicase-moi expression and for treatment of diseases associated with expression of helicase-moi are provided.
Claims26
A compound 16 to 50 nucleobases in length targeted to nucleobases 427 through 5785 of a coding region of a nucleic acid molecule encoding human helicase-moi of SEQ ID NO:3, wherein said compound specifically hybridizes with said region and inhibits the expression of human helicase-moi.
A compound up to 50 nucleobases in length comprising at least a 16-nucleobase portion of SEQ ID NO:
- 14, 15, 19, 22, 23, 24, 25, 26, 27, 28, 30, 31, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 49, 53, 54, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 72, 76, 78, 79, 80, 81, 82, 83, 84, 85, 87, 88, 90 or 91 which inhibits the expression of human helicase-moi.
Dependencies are inferred from the claim text.