Mitogen-activated protein kinase P38-2 and methods of use therefor
AssigneeSignal Pharmaceuticals, LLC
InventorsBernd Stein, Maria X. H. Yang, David B. Young
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Abstract
Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.
Claims11
An isolated DNA molecule encoding a polypeptide comprising the amino acid sequence as recited in SEQ ID NO:2 or a polypeptide variant of the polypeptide SEQ ID NO:2 that differs only in modifications at no more than 20% of the amino acid residues over the full length of the polypeptide, wherein said polypeptide is capable of phosphorylation of a substrate.
An isolated DNA molecule encoding a polypeptide consisting of the sequence of SEQ ID NO:3.
An isolated DNA molecule encoding a polypeptide comprising the sequence of SEQ ID NO:4.
Dependencies are inferred from the claim text.