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US 6,444,452 B1Granted
Process for recovering statin compounds from a fermentation broth
AssigneeBiogal Gyogyszergyar Rt.
InventorsVilmos Keri, Lajos Deak, Ilona Forgacs, Csaba Szabo, Edit Arvai Nagyne
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Abstract
A novel process for recovering a compound from a fermentation broth that includes the stages of forming an enriched solution of the compound by extraction, obtaining a salt of the compound from the enriched solution, purifying a salt of the compound and trans-salifying the salt of the compound to a metal salt of the compound is disclosed.
Claims44
A process for isolating a sodium salt of a compound selected from the group consisting of pravastatin, compactin and lovastatin, from a fermentation broth comprising the steps of:
- a. forming an enriched solution of the compound;
- b. obtaining a salt of the compound from the enriched solution;
- c. purifying the salt of the compound;
- d. trans-salifying the salt of the compound to a sodium salt of the compound by:
- i. liberating the compound from its salt,
- ii. contacting the compound with an aqueous sodium hydroxide solution thereby forming an aqueous solution of the sodium salt of the compound, and
- iii. scavenging excess sodium ions by contacting the aqueous solution of the sodium salt of the compound with a water-insoluble ionic exchange resin;
- and
- e. isolating the sodium salt of the compound from the aqueous solution of the sodium salt of the compound.
6 more elements
Dependencies are inferred from the claim text.