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US 6,444,440 B1Granted
Vanilloid receptor-2
AssigneeHuman Genome Sciences, Inc.
InventorsPaul E. Young, Steven M. Ruben
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AssigneeHuman Genome Sciences, Inc.
InventorsPaul E. Young, Steven M. Ruben
Estimating the term…
The present invention relates to vanilloid receptor-2, a novel member of the vanilloid receptor family. The invention provides isolated nucleic acid molecules encoding human VR2 receptors. VR2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of VR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of VR2 receptors. Further provided are therapeutic methods for treating disease states including, but not limited to, chronic pain syndromes, congenital pain insensitivity, inflammation, ischemia, host defense dysfunction, immune surveillance dysfunction, arthritis, multiple sclerosis, autoimmunity, immune dysfunction, and allergy.
An isolated polynucleotide comprising a nucleic acid selected from the group consisting of:
An isolated polynucleotide comprising a nucleic acid encoding a first amino acid sequence at least 95% identical to a reference amino acid sequence selected from the group consisting of:
An isolated polynucleotide comprising a first nucleic acid which hybridizes in a wash solution consisting of 0.1×SSC at 65° C., to a second nucleic acid selected from the group consisting of:
The host cell of claim herein said isolated polynucleotide is operably associated with a heterologous regulatory sequence.
A method of producing a polypeptide comprising culturing the host cell of claim under conditions such that a polypeptide is expressed, and recovering said polypeptide.
Dependencies are inferred from the claim text.