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US 6,444,434 B1Granted
FVIIa/TF activity inhibiting compounds
AssigneeNovo Nordisk A/S
InventorsPalle Jakobsen, Egon Persson
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Abstract
The invention relates to compounds inhibiting the activation of FX to FXa by TF/FVIIa. The compounds are anticoagulants. The invention also relates to a method of identifying a drug candidate.
Claims5
A compound having an inhibitory action on Factor VII-Tissue Factor (FVII-TF) activity, wherein said compound exhibits:
- (i) half-maximal inhibition at a concentration of 20 μM or less in a FX activation assay,
- (ii) half-maximal inhibition at a concentration of 100 μM or more in a FXa amidolytic assay, and
- (iii) half-maximal inhibition at a concentration of 20 μM or more in a TF/FVIIa amidolytic assay.
Dependencies are inferred from the claim text.