Ndr2-related proteins
AssigneeIncyte Genomics, Inc.
InventorsSusan G. Stuart, Janice Au-Young, Jennifer L. Hillman, Purvi Shah, Henry Yue
Life of this patent
Estimating the term…
Abstract
The invention provides cDNA which encode Ndr2-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly cancers of the intestine, breast, uterus, liver, brain, and kidney. The invention additionally provides expression vectors and host cells for the production of the proteins and a transgenic model system.
Claims14
An isolated cDNA comprising a nucleic acid sequence encoding a protein selected from the amino acid sequence of SEQ ID NO:1 and SEQ ID NO:2, or the complement thereof.
An isolated cDNA comprising a nucleic acid sequence selected from:
- a) SEQ ID NO:3 and SEQ ID NO:11 or the complement thereof;
- b) a fragment of SEQ ID NO:3 selected from SEQ ID NOs:4-10 or the complement thereof;
- c) a fragment of SEQ ID NO:11 selected from SEQ ID NOs:
- 12-15 or the complement thereof;
- and
- d) a variant of SEQ ID NO:3 or SEQ ID NO:11 selected from SEQ ID NOs:16-31 or the complement thereof.
An isolated cDNA comprising the nucleic acid sequence of SEQ ID NO:3.
An isolated cDNA comprising the nucleic acid sequence of SEQ ID NO:11.
Dependencies are inferred from the claim text.