Polymorphisms in a diacylglycerol acyltransferase gene, and methods of use thereof
AssigneeThe Regents of the University of California
InventorsErwin H. Ludwig, Robert V. Farese, Thomas L. Innerarity, Sylvaine Cases
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Abstract
The present invention provides isolated an polynucleotide comprising a polymorphic nucleotide sequence from a diacylglycerol acyltransferase (DGAT) gene, wherein at least one a polymorphism is associated with a condition relating to DGAT activity. The invention further provides diagnostic assays for detecting the presence in a nucleic acid sample of a polymorphism in a DGAT gene that is associated with a condition relating to DGAT activity, and for detecting a propensity to develop a condition associated with DGAT activity. The invention further provides treatment methods.
Claims13
A method of detecting a propensity of an individual to develop a condition associated with DGAT activity, comprising:
- analyzing a polynucleotide sample derived from said individual for the presence of a polymorphism in a diacylglycerol acyltransferase (DGAT) gene, wherein said polymorphism is associated with DGAT activity, and wherein said polymorphism is a T to C transition in the DGAT promoter at a position 78 bases 3′ of the transcriptional start site of the DGAT gene, wheein the presence of said polymorphism is indicative of the propensity of an individual to develop a condition associated with DGAT activity.
A method of detecting a polymorphism associated with a condition related to abnormal fat storage in an individual, comprising:
- analyzing a polynucleotide sample from said individual for the presence of a polymorphism in a diacylglycerol acyltransferase (DGAT) gene, wherein said polymorphism is associated with a condition associated with abnormal fat storage associated with high levels of DGAT activity, and wherein said polymorphism is a T to C transition 78 bases 3′ of the transcriptional start site of the DGAT gene, wherein the presence of said polymorphism is indicative of a polymorphism associated with a condition related to abnormal fat storage in an individual.
A method of genetically diagnosing a condition associated with DGAT activity in an individual, comprising:
- analyzing a polynucleotide sample from said individual for the presence of a polymorphism in a diacylglycerol acyltransferase (DGAT) gene, wherein said polymorphism is associated with a condition associated with DGAT activity, and wherein said polymorphism is a T to C transition 78 bases 3′ of the transcriptional start site of the DGAT gene, wherein the presence of said polymorphism is indicative of genetically diagnosing a condition associated with DGAT activity in an individual.
A method of detecting a propensity of an individual to become obese, comprising:
- analyzing a polynucleotide sample derived from said individual for the presence of a polymorphism in a diacylglycerol acyltransferase (DGAT) gene, wherein said polymorphism is a T to C transition 78 bases 3′ of the transcriptional start site the DGAT gene, and wherein the presence of said polymorphism indicates that the individual has a propensity to become obese.
A method of detecting a propensity of an individual to develop a condition associated with obesity, comprising:
- analyzing a polynucleotide sample derived from said individual for the presence of a polymorphism in a diacylglycerol acyltransferase (DGAT) gene, wherein said polymorphism is a T to C transition 78 bases 3′ of the transcriptional start site of the DGAT gene, and wherein the presence of said polymorphism indicates that the individual has a propensity to develop a condition associated with obesity.
Dependencies are inferred from the claim text.