Self assembling monolayer compositions
AssigneeSurModics, Inc.
InventorsPatrick E. Guire, Kristin S. Taton
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Abstract
A surface coating composition for providing a self-assembling monolayer, in stable form, on a material surface or at a suitable interface, as well as a method of preparing such a composition and a method of using such a composition to coat a surface, such as the surface of an implantable medical device, in order to provide the surface with desirable properties. The method provides the covalent attachment of a SAM to a surface in a manner that substantially retains or improves the characteristics and/or performance of both the SAM and the surface itself. Covalent attachment is accomplished by the use of one or more latent reactive groups, e.g., provided by either the surface and/or by the SAM-forming molecules themselves.
Claims28
A method of providing a self-assembling monolayer on a surface, the method comprising the steps of:
- a) providing on the surface both latent reactive groups and a monolayer formed of self-assembling monolayer molecules, and b) activating the latent reactive groups under conditions suitable to either covalently attach the self-assembled monolayer to the surface and/or to form a stable monolayer film on the surface, by initiating polymerization of suitable groups provided by self-assembling monolayer molecules themselves and/or by forming intermolecular bonds between the self-assembling monolayer molecules.
A method of providing a self-assembling monolayer on a surface, the method comprising the steps of:
- a) providing on the surface both latent reactive groups and a monolayer formed of self-assembling monolayer molecules, and b) activating the latent reactive groups under conditions suitable to covalently attach the self-assembled monolayer to the surface, wherein
- a) the SAM-forming molecules have themselves been provided with latent reactive groups,
- b) the self-assembling monolayer molecules comprise amphiphilic molecules comprised of a hydrophobic domain which spontaneously associates with the surface from an aqueous solution, and of a hydrophilic domain which allows the molecule to be dispersed in water and which remains associated with the aqueous phase after monolayer formation on the surface,
- c) the surface is provided by a material selected from organosilane-pretreated glasses, organosilane-pretreated silicon materials, silicon hydrides, and polymeric materials, and
- d) the latent reactive groups comprise photoreactive groups in the form of photoreactive aryl ketones.
A composition comprising a self-assembling monolayer molecules derivatized with one or more latent reactive groups.
Dependencies are inferred from the claim text.