Storage-stable particle, in particular carrier for carrier-bound reactions, and methods of producing said particle
AssigneeAbion Beteiligungs-und Verwaltungsgesellschaft mbH
InventorsDmitri Plaksine, Elena Gromakovskaia, Christoph Erhardt
Life of this patent
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Abstract
A particle resistant to storage of at least one first and at least one second component, wherein said second component of at least one crosslinkable polymer as a shell at least partially envelops and/or encloses said first component as a core and said first component has at least one ascertainable property, obtainable by reacting said first component with the crosslinkable polymer and subsequently reacting the formed product with a crosslinking agent such that the first component with resistance to storage remains within the second component.
Claims16
A reactive particle comprising:
- a) a shell of crosslinked polymer, wherein the crosslinked polymer is bound to at least one reactive component selected from the group consisting of an enzyme, an enzyme substrate, an antibody, an antigen, biotin, streptavidin, RNA, and DNA, the crosslinked polymer reticularly enclosing
- b) a core of material having at least one property selected from the group consisting of absorptivity of electro magnetic waves, emissivity of electromagnetic waves, mass magnetism, dielectricity, radioactivity, size distribution, pharmacological activity, biological activity, and catalytic activity,
- the particle produced by the process comprising the steps of:
- reacting at least one crosslinkable polymer, wherein the crosslinkable polymer is bound to the at least one reactive component, with the material having at least one property to produce an intermediate comprising (i) the crosslinkable polymer enveloping (ii) a core of the material followed by
- reacting the at least one crosslinkable polymer with a crosslinking agent, at a ratio crosslinking agent/crosslinkable polymer of at least 10/1, to crosslink the polymer to form a molecular network and, thereby, reticularly enclose the core.
A process for the production of a particle having a core and a shell comprising the steps of:
- reacting at least one crosslinkable polymer, wherein the crosslinkable polymer is bound to at least one reactive component selected from the group consisting of an enzyme, an enzyme substrate, an antibody, an antigen, biotin, streptavidin, RNA, and DNA, with a material having at least one property selected from the group consisting of absorptivity of electro magnetic waves, emissivity of electromagnetic waves, mass magnetism, dielectricity, radioactivity, size distribution, pharmacological activity, biological activity, and catalytic activity, to produce an intermediate comprising (i) the crosslinkable polymer enveloping (ii) the material followed by
- reacting the at least one crosslinkable polymer with a crosslinking agent, at a ratio crosslinking agent/crosslinkable polymer of at least 10/1, to crosslink the polymer to form a molecular network and, thereby, reticularly enclose the material and, thereby, effect said particle.
Dependencies are inferred from the claim text.