Back to results
US 6,444,217 B1Granted
Drug delivery devices, and methods of use
AssigneeUniversity of Washington
InventorsConnie Sau-Kuen Kwok, Buddy D. Ratner, Pierre D. Mourad, Lawrence A. Crum
Life of this patent
Estimating the term…
Abstract
The present invention provides biomedical devices, such as implantable drug delivery devices that possess a surface layer adapted to retain, and controllably release, drug molecules for administration to a subject. The present invention also provides methods of delivering a drug to a subject, the methods utilizing biomedical devices of the invention.
Claims17
A biomedical device comprising:
- (a) a polymeric or hydrogel substrate;
- and
- (b) a surface layer comprising a multiplicity of C10 to C22 unbranched alkyl molecules, wherein:
- (1) the multiplicity of alkyl molecules define a multiplicity of spaces therebetween;
- (2) each member of the multiplicity of alkyl molecules possesses a proximal end and a distal end, the proximal end being covalently linked to the substrate;
- and
- (3) the surface layer has an ordered state and a less ordered state, the surface layer being reversibly convertible to the less ordered state from the ordered state in response to an effective amount of sound or thermal energy.
4 more elements
A method of making a biomedical device comprising a surface layer, said method comprising the steps of:
- (a) disposing a multiplicity of drug molecules within a polymeric or hydrogel substrate;
- and
- (b) covalently attaching a multiplicity of C10 to C22 unbranched alkyl molecules to the surface of the substrate by forming a covalent linkage between an end group on each member of the multiplicity of C10 to C22 unbranched alkyl molecules and a reactive group on the substrate, thereby forming a surface layer on the substrate wherein:
- (1) the multiplicity of alkyl molecules define a multiplicity of spaces therebetween;
- (2) each member of the multiplicity of alkyl molecules possesses a proximal end and a distal end, the proximal end being covalently linked to the substrate;
- and
- (3) the surface layer has an ordered state and a less ordered state, the surface layer being reversibly convertible to the less ordered state from the ordered state in response to an effective amount of sound or thermal energy.
4 more elements
A method of delivering a drug to a subject, said method comprising the steps of:
- (a) introducing into a subject a device comprising:
- (1) a polymeric or hydrogel substrate comprising a multiplicity of drug molecules;
- and
- (2) a surface layer comprising a multiplicity of C10 to C22 unbranched alkyl molecules, wherein:
- (i) the multiplicity of alkyl molecules define a multiplicity of spaces therebetween;
- (ii) a multiplicity of drug molecules are disposed within said spaces;
- (iii) each member of the multiplicity of alkyl molecules possesses a proximal end and a distal end, the proximal end being covalently linked to the substrate;
- and
- (iv) the surface layer has an ordered state and a less ordered state, the surface layer being reversibly convertible to the less ordered state from the ordered state in response to an effective amount of sound or thermal energy;
- and
- (b) subjecting the device to an amount of sound or thermal energy effective to induce release of the drug molecules from the surface layer.
8 more elements
Dependencies are inferred from the claim text.