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US 6,444,209 B1Granted
Hybrid botulinal neurotoxins
AssigneeWisconsin Alumni Research Foundation
InventorsEric A. Johnson, Michael C. Goodnough, Marite Bradshaw, William H. Tepp
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Abstract
A hybrid botulinal neurotoxin is disclosed. In one embodiment, the neurotoxin comprises a combination of a botulinal neurotoxin heavy chain and light chain, wherein the light chain and heavy chain are not of the same serotype and wherein the heavy and light chains are linked by a homobifunctional sulfydryl linker. A method for creating hybrid neurotoxins comprised of different functional domains is also disclosed.
Claims5
A hybrid botulinal neurotoxin comprising:
- (a) a botulinal neurotoxin light chain;
- and
- (b) a botulinal neurotoxin heavy chain, wherein the light chain and heavy chain are not of the same serotype and wherein the light and heavy chains are linked by a reducible, disulfide homobifunctional linker and wherein the specific toxicity of the neurotoxin is it least 106 LD50/mg protein in vivo.
Dependencies are inferred from the claim text.