Immunotherapy of tumor with monoclonal antibody against the 17-1A antigen

A method for treating a gastrointestinal tumor comprising administering to a patient afflicted with a gastrointestinal tumor, a murine monoclonal antibody which specifically binds to an epitope of 17-1A antigen, said antibody being administered in multiple doses of about 100 milligrams or more per dose for a total of about 0.1 to 5 grams of antibody, wherein the multiple doses are administered such that the patient sustains a high plasma level of antibody during the therapy.

A method for treating a gastrointestinal tumor comprising administering to a patient afflicted with a gastrointestinal tumor, a murine monoclonal antibody which specifically binds to an epitope of 17-1A antigen, said antibody being administered as adjuvant therapy in multiple doses of 100 milligrams or more per dose for a total of about 0.1 to 5 grams of antibody.

A method for treating a gastrointestinal tumor comprising administering to a patient afflicted with a gastrointestinal tumor, a murine monoclonal antibody which specifically binds to an epitope of 17-1A antigen, said antibody being administered in multiple doses, wherein the first dose is of about 400 milligrams or more per dose and the second or subsequent dose is of about 100 milligrams or more per dose, for a total of about 0.1 to 5 grams of antibody.

A method for treating a carcinoma originating from a 17-1A-positive tissue comprising administering to a patient afflicted with a carcinoma originating from a 17-1A-positive tissue, a monoclonal antibody which specifically binds to an epitope of 17-1A antigen, said antibody being administered in multiple doses of about 100 milligrams or more per dose, wherein the multiple doses are administered such that the patient sustains a high plasma level of antibody during therapy.

A method for treating a carcinoma originating from a 17-1A-positive tissue comprising administering to a patient afflicted with a carcinoma originating from a 17-1A-positive tissue, a monoclonal antibody which specifically binds to an epitope of 17-1A antigen, said antibody being administered in multiple doses, wherein the first dose is of about 400 milligrams or more per dose and the second or subsequent dose is of about 100 milligrams or more per dose.

A method for treating a carcinoma originating from a 17-1A-positive tissue comprising administering to a patient afflicted with a carcinoma originating from a 17-1A-positive tissue, a monoclonal antibody which specifically binds to an epitope of 17-1A antigen, said antibody being administered as adjuvant therapy in multiple doses of about 100 milligrams or more per dose.

A method for treating a carcinoma originating from bronchial tissue or tissue of glandular structure comprising administering to a patient afflicted with a carcinoma originating from bronchial tissue or tissue of glandular structure, a monoclonal antibody which specifically binds an epitope of 17-1A antigen, said antibody being administered in multiple doses for a total dose of about 0.1 to 5 grams.