Reduction compositions and processes for making the same
AssigneeFMC Corporation
InventorsAnne Pautard-Cooper, Eric John Granger, Philip Franklin Sims, James Anthony Schwindeman, John Francis Engel, Terry Lee Rathman
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Abstract
Novel reduction compositions are prepared from an active hydride, an additive, and a Lewis base in a hydrocarbon solvent. Such compositions can provide a superior reducing system for organic substrates.
Claims28
A process for the preparation of an unfiltered composition for the reduction of organic substrates, comprising the steps of, in sequence:
- adding at least one Lewis base to at least one additive to form a preformed Lewis base/additive slurry;
- and
- thereafter adding a preformed slurry of at least one active hydride to said preformed Lewis base/additive slurry under conditions sufficient to form an unfiltered reduction composition having reducing properties.
A process for the preparation of an unfiltered composition for the reduction of organic substrates, comprising in sequence the steps of:
- adding 45 to 80 mole % tetrahydrofuran to 5 to 20 mole % lithium chloride to form a preformed slurry thereof;
- and
- thereafter adding 5 to 20 mole % of a slurry of sodium aluminum hydride in a hydrocarbon solvent to said preformed tetrahydrofuran/lithium chloride slurry.
An unfiltered composition for the reduction of organic substrates, comprising an unfiltered composition by the process comprising the steps of, in sequence:
- adding at least one Lewis base to at least one additive to form a preformed slurry thereof;
- and
- adding a slurry of at least one active hydride to said preformed Lewis base/additive slurry under conditions sufficient to produce a reduction composition having reducing properties.
An unfiltered composition for the reduction of organic substrates, comprising an unfiltered composition prepared by the process comprising the steps of, in sequence:
- adding 45 to 80 mole % tetrahydrofuran to 5 to 20 mole % lithium cholride to form a preformed Lewis base/lithium chloride slurry;
- and
- adding 5 to 20 mole % of a preformed slurry of sodium aluminum hydride in a hydrocarbon solvent to said preformed tetrahydrofuran/lithium chloride slurry.
A process for reducing at least one functional group of an organic substrate, comprising:
- adding at least one Lewis base to at least one additive to form a preformed Lewis base/additive slurry;
- thereafter adding a preformed slurry of at least one active hydride to said preformed Lewis base/additive slurry under conditions sufficient to form an unfiltered reduction composition having reducing properties;
- and
- contacting said organic substrate with said unfiltered reduction composition.
Dependencies are inferred from the claim text.