Methods for treating conditions and illnesses associated with abnormal vasculature
AssigneeAkorn, Inc.
InventorsRobert W. Flower, Abu Alam
Life of this patent
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Abstract
Use of radiation-absorbing dyes (e.g., indocyanine green (ICG), fluorescein, rose bengal) and photodynamic dyes (e.g., hematoporphyrins, aminolevulinic acids, porphyrins, merocyanines, porphycenes, porfimer sodium, verteporfin, Photofrin II, PH-10, chlorins, zinc phthalocyanine, purpurins, pheophorbides, monoclonal antibody-dye conjugates of any of the foregoing dyes) for the treatment of conditions associated with abnormal vasculature, including, generally, lesions, and, more specifically, tumors (cancerous and benign) and choroidal neovascularization (CNV) associated with age-related macular degeneration (ARMD).
Claims41
A method for treating a lesion of an animal, the animal having a blood vessel that carries blood into the lesion, comprising
- (a) administering a first composition comprising a dye suitable for use in photodynamic therapy and a pharmaceutically-acceptable carrier to the animal to fill at least a portion of the lesion with the first composition;
- (b) applying radiation to the lesion of a type and in an amount sufficient to excite the dye residing therein and cause the lesion to undergo photodynamic therapy;
- (c) administering a second composition comprising a dye suitable for use in dye-enhanced photocoagulation and a pharmaceutically-acceptable carrier to the animal to fill at least part of the blood vessel that carries blood into the lesion;
- and
- (d) applying radiation to the blood vessel as the second composition at least partially fills the vessel of a type and in an amount sufficient to excite the dye therein, thereby reducing the rate of blood flow through the vessel.
A method for treating a lesion of an animal, the animal having a blood vessel that carries blood into the lesion, comprising
- (a) administering a first composition comprising a dye suitable for use in photodynamic therapy selected from the group consisting of hematoporphyrins, aminolevulinic acids, porphyrins, merocyanines, porphycenes, verteporfin, porfimer sodium, PH-10, Photofrin II, chlorins, zinc phthalocyanine, purpurins, pheophorbides, monoclonal anti-body conjugates of any of the foregoing dyes, and mixtures thereof and a pharmaceutically-acceptable carrier to the animal to fill at least a portion of the lesion with the first composition;
- (b) applying radiation to the lesion of a type and in an amount sufficient to excite the dye residing therein and cause the lesion to undergo photodynamic therapy;
- (c) administering a second composition comprising a dye selected from the group consisting of indocyanine green, fluorescein, rose bengal, lutetium texaphyrin and mixtures thereof and a pharmaceutically-acceptable carrier to the animal to at least partially fill the blood vessel that carries blood into the lesion with the second composition;
- and
- (d) applying radiation to the blood vessel as the second composition at least partially fills the vessel of a type and in an amount sufficient to excite the dye therein and thereby reduce the rate of blood flow through the vessel.
A method for treating CNV in an animal, the animal having a blood vessel that carries blood into the CNV, comprising
- (a) administering a first composition comprising a dye suitable for use in photodynamic therapy and a pharmaceutically-acceptable carrier to the animal to fill at least part of the CNV with the first composition;
- (b) applying radiation to the CNV of a type and in an amount sufficient to excite the dye residing therein and cause the lesion to undergo photodynamic therapy;
- (c) administering a second composition comprising a dye suitable for use in dye-enhanced photocoagulation and a pharmaceutically-acceptable carrier to the animal to fill at least part of the blood vessel that carries blood into the CNV with the second composition;
- and
- (d) applying radiation to the blood vessel as the second composition at least partially fills the vessel of a type and in an amount sufficient to excite the dye therein, thereby reducing the rate of blood flow through the vessel.
A method for damaging a tumor in an animal, the animal having a blood vessel that carries blood into the tumor, comprising
- (a) administering a first composition comprising a dye suitable for use in photodynamic therapy and a pharmaceutically-acceptable carrier to the animal to fill at least a part of the tumor with the first composition;
- (b) applying radiation to the tumor of a type and in an amount sufficient to excite the dye residing therein and cause the lesion to undergo photodynamic therapy, wherein the tumor is damaged;
- (c) administering a second composition comprising a dye suitable for use in dye-enhanced photocoagulation and a pharmaceutically-acceptable carrier to the animal to fill at least part of the blood vessel that carries blood into the tumor;
- and
- (d) applying radiation to the blood vessel as the second composition at least partially fills the vessel of a type and in an amount sufficient to excite the dye therein, thereby reducing the rate of blood flow through the blood vessel.
Dependencies are inferred from the claim text.