US 6,441,253 B1Granted

Method for the synthesis of taxanes

AssigneeFlorida State University

InventorsRobert A. Holton, Phong Vu, Tawfik Gharbaoui, Vincent Reboul

Life of this patent

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Abstract

A process for the preparation of a compound having the formula: the process comprising treating a compound having the formula: with an alkyl metal species or with a Lewis acid in the presence of a tertiary amine base, wherein P2 is hydrogen or a hydroxyl protecting group.

Claims8

Dependent claims

A process for the preparation of a compound having the formula:

the process comprising treating a compound having the formula:
with an alkyl metal species or with a Lewis acid in the presence of a tertiary amine base, wherein P2 is hydrogen or a hydroxyl protecting group.

Dependencies are inferred from the claim text.

Facts

Application: 09/617,555Filed 17 Jul 2000 · division
Priority: 21 Aug 1997
Granted: 27 Aug 2002
Term ends: Not estimatedThe source records don’t support an estimate.

Classification19 codes

C07D 305/14
Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms: condensed with carbocyclic rings or…
C07C 29/56
Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring: by isomerisation
C07C 35/37
Polycyclic, at least one hydroxy group bound to a condensed ring system: with a hydroxy group on a condensed system having three rings
C07C 43/23
Having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring: containing hydroxy or O-metal groups

Family

Application60/056,210Us provisional application · filed 21 Aug 1997
Application09/136,827Parent of this division · filed 20 Aug 1998
US 6,111,144 AParent of this division
US 6,441,253 B1This patent

From the US filing history. Foreign family members aren’t listed.

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