Derivatives and analogs
AssigneeUniversity of Southern California
InventorsCharles E. McKenna, Zeng-Min Li, Xue-Wei Liu
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Abstract
Preparation of phosphonoformic acid analogues containing one, two, three, or more sulfur atoms are described, with specific examples. Such compounds, not excluding cognates, derivatives, and homologues thereof, are proposed to be used directly, or as prodrugs, in treating viral infections, including but not limited to HIV, herpesviruses including HSV, EBV, VZV, CMV, HSV-6 and HSV-8 (Kaposi's sarcoma); HPV; rhinoviruses; and hepatitis-linked viruses. They are also proposed to be used in treating neoplasms, and for diagnosis and therapy of diseases of bone metabolism. The compounds of the present invention are also designed as to create novel biologically active compounds or prodrugs.
Claims5
A substantially pure thio-analog of phosphonoformic acid comprising the formula:
- wherein R1 and R2 are each independently selected from alkyl, aryl, H, and cation, R3 is independently selected from alkyl, aryl, H, cation, and a prodrug moiety, and X1, X2, X3, X4, and X5 are each independently selected from O and S, provided that:
- (a) at least one of X1-X3 is S;
- (b) when X1 is S, then either (i) R1 or R2 is alkyl, aryl, or H, or (ii) at least one of X2, X3, X4, and X5 is also S;
- (c) R1 and R2 are different provided that R3 has 1 carbon atom.
A substantially pure thio-analog of phosphonoformic acid comprising the formula:
A substantially pure thio-analog of phosphonoformic acid comprising the formula:
A substantially pure thio-analog of phosphonoformic acid comprising the formula:
A substantially pure thio-analog of phosphonoformic acid comprising the formula:
Dependencies are inferred from the claim text.