Method for making hydroxy-25-ene-vitamin D compounds
AssigneeBone Care International, Inc.
InventorsHans Wynberg, Ton Vries, Kees Pouwer
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Abstract
The present invention provides a method for preparing a novel class of vitamin D compounds in which the C-25 or equivalent position has a double bond. In addition, the side chain is optionally extended by one or two methylene or methyne groups. The compounds prepared by the method of the present invention are of value as prodrugs for active 1α, 24-dihydroxylated vitamin D compounds.
Claims7
A method of making a hydroxy-25-ene-vitamin D compound comprising the step of reacting a 2,3-dimethyl-3-butene phenyl sulfone with a hydroxyl-protected C-22 aldehyde of a vitamin D, the hydroxyl-protected C-22 aldehyde of vitamin D being hydroxyl-protected at C-3 or at C-3 and C-1.
A method of making a hydroxy-25-ene-vitamin D2 compound comprising the step of reacting a 2,3-dimethyl-3-butene phenyl sulfone with a hydroxyl-protected C-22 aldehyde of a vitamin D2, the hydroxyl-protected C-22 aldehyde of vitamin D2 being hydroxyl-protected at C-3 or at C-3 and C-1.
Dependencies are inferred from the claim text.