Podophyllotoxin dimer as DNA topoisomerase II inhibitors, and a process for the preparation therefore
AssigneeCouncil of Scientific and Industrial Research
InventorsAhmed Kamal, Laxman Eltepu, Arifuddin Mohammed, Gollapalli Bhasker Ramesh Khanna
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Abstract
The present invention discloses novel podophyllotoxin dimers having structural formula I wherein R is H or CH3 and Z is aryl or subsituted aryl compound selected form the group counting of phenylene, naphthalene, p-terpbhnyl, dimethoxy benzidine and diphenyl ether and a process for the preparation of said novel podophyllotoxin dimers. The new podophyllotoxin dimers, pawculaty 4-arylamino derivatives of the podophyllotoxin dimers of the present invention as useful as potent inhibitors of DNA-topoisomerase II and are also useful as antitumour agents.
Claims9
A podophyllotoxin dimer having structural formula 3-8
- wherein R is H or CH3 and Z is an aryl or substituted aryl compound selected from the group consisting of phenylene, naphthalene, p-terphenyl, dimethoxy benzidine and diphenyl ether.
A process as claimed in 2, wherein the phase transfer catalyst used is selected from Bu4N+Br− and Bu4N+I−.
Dependencies are inferred from the claim text.